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2008.81: Tumour glycolysis: the many faces of HIF

2008.81: C.J. Kelly, K. Smallbone and J.M. Brady (2008) Tumour glycolysis: the many faces of HIF. Journal of Theoretical Biology, 254 (2). pp. 508-513. ISSN 0022-5193

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DOI: 10.1016/j.jtbi.2008.05.025

Abstract

We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1α (HIF-1α), and growth-factor signalling cascades, which are frequently mutated in cancers. Our findings demonstrate the importance of considering both environmental and intracellular regulation when interpreting tumour metabolism for diagnostic or prognostic purposes. To illustrate this, we demonstrate the potential impact of this multi-factorial regulation on the kinetics of radiolabelled glucose analogues, used in positron emission tomography (PET).

Item Type:Article
Uncontrolled Keywords:Molecular imaging
Subjects:MSC 2000 > 34 Ordinary differential equations
MSC 2000 > 92 Biology and other natural sciences
MIMS number:2008.81
Deposited By:Dr Kieran Smallbone
Deposited On:08 September 2008

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