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2008.88: Mathematical modelling of tumour acidity

2008.88: K. Smallbone, R.A. Gatenby and P.K. Maini (2008) Mathematical modelling of tumour acidity. Journal of Theoretical Biology, 255 (1). pp. 106-112. ISSN 0022-5193

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DOI: 10.1016/j.jtbi.2008.08.002

Abstract

Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as the existence of the benign steady state, or predicted incorrectly the size of the inter-tissue gap. Here we show that taking proper account of quiescence ameliorates these drawbacks as well as revealing novel behaviour. The simplicity of the model allows us to fully identify the key parameters controlling different aspects of behaviour.

Item Type:Article
Uncontrolled Keywords:Tumour invasion; Glycolytic phenotype; Acidity; Mathematical modelling
Subjects:MSC 2000 > 35 Partial differential equations
MSC 2000 > 92 Biology and other natural sciences
MIMS number:2008.88
Deposited By:Dr Kieran Smallbone
Deposited On:10 October 2008

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