2008.88: Mathematical modelling of tumour acidity
2008.88: K. Smallbone, R.A. Gatenby and P.K. Maini (2008) Mathematical modelling of tumour acidity. Journal of Theoretical Biology, 255 (1). pp. 106-112. ISSN 0022-5193
Full text available as:
 | PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 369 Kb |
DOI: 10.1016/j.jtbi.2008.08.002
Abstract
Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as the existence of the benign steady state, or predicted incorrectly the size of the inter-tissue gap. Here we show that taking proper account of quiescence ameliorates these drawbacks as well as revealing novel behaviour. The simplicity of the model allows us to fully identify the key parameters controlling different aspects of behaviour.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Tumour invasion; Glycolytic phenotype; Acidity; Mathematical modelling |
| Subjects: | MSC 2000 > 35 Partial differential equations MSC 2000 > 92 Biology and other natural sciences |
| MIMS number: | 2008.88 |
| Deposited By: | Dr Kieran Smallbone |
| Deposited On: | 10 October 2008 |
Download Statistics: last 4 weeks
Repository Staff Only: edit this item