Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

Barouch, Dan H. and O'Brien, Kara L. and Simmons, Nathaniel L. and King, Sharon L. and Abbink, Peter and Maxfield, Lori F. and Sun, Ying-Hua and La Porte, Annalena and Riggs, Ambryice M. and Lynch, Diana M. and Clark, Sarah L. and Backus, Katherine and Perry, James R. and Seaman, Michael S. and Carville, Angela and Mansfield, Keith G. and Szinger, James J. and Fischer, Will and Muldoon, Mark and Korber, Bette (2010) Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nature Medicine, 16 (3). pp. 319-323. ISSN 1546-170X

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Abstract

The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development. Antigens derived from natural HIV-1 sequences have elicited only a limited breadth of cellular immune responses in nonhuman primate studies and clinical trials to date. Polyvalent 'mosaic' antigens, in contrast, are designed to optimize cellular immunologic coverage of global HIV-1 sequence diversity. Here we show that mosaic HIV-1 Gag, Pol and Env antigens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors markedly augmented both the breadth and depth without compromising the magnitude of antigen-specific T lymphocyte responses as compared with consensus or natural sequence HIV-1 antigens in rhesus monkeys. Polyvalent mosaic antigens therefore represent a promising strategy to expand cellular immunologic vaccine coverage for genetically diverse pathogens such as HIV-1.

Item Type: Article
Additional Information: The advance online publication appeared 21 Feb 2010.
Uncontrolled Keywords: HIV-1, mosaic vaccine, cytotoxic T lymphocyte
Subjects: MSC 2010, the AMS's Mathematics Subject Classification > 92 Biology and other natural sciences
Depositing User: Dr Mark Muldoon
Date Deposited: 23 Feb 2010
Last Modified: 20 Oct 2017 14:12
URI: http://eprints.maths.manchester.ac.uk/id/eprint/1420

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