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2012.75: Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens

2012.75: Sampa Santra, Mark Muldoon, Sydeaka Watson, Adam Buzby, Harikrishnan Balachandran, Kevin R. Carlson, Linh Mach, Wing-Pui Kong, Krishna McKee, Zhi-Yong Yang, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Bette T, Korber and Norman L. Letvin (2012) Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens. Virology, 248 (2). pp. 121-127. ISSN 0042-6822

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DOI: 10.1016/j.virol.2012.03.012

Abstract

To create an HIV-1 vaccine that generates sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus, we have been exploring vaccines based on consensus and mosaic protein designs. Increasing the valency of a mosaic immunogen cocktail increases epitope coverage but with diminishing returns, as increasingly rare epitopes are incorporated into the mosaic proteins. In this study we compared the immunogenicity of 2-valent and 3-valent HIV-1 envelope mosaic immunogens in rhesus monkeys. Immunizations with the 3-valent mosaic immunogens resulted in a modest increase in the breadth of vaccine-elicited T lymphocyte responses compared to the 2-valent mosaic immunogens. However, the 3-valent mosaic immunogens elicited significantly higher neutralizing responses to Tier 1 viruses than the 2-valent mosaic immunogens. These findings underscore the potential utility of polyvalent mosaic immunogens for eliciting both cellular and humoral immune responses to HIV-1.

Item Type:Article
Uncontrolled Keywords:HIV-1 vaccine, mosaic immunogens, T cells
Subjects:MSC 2000 > 92 Biology and other natural sciences
MIMS number:2012.75
Deposited By:Dr Mark Muldoon
Deposited On:07 August 2012

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