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2006.63: The Ariel Project: A prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy

2006.63: R. B. Van Dyke, B. T. Korber, E. Popek, C. Macken, S. M. Widmayer, A. Bardeguez, I. C. Hanson, A. Wiznia, K. Luzuriaga, R. R. Viscarello, S. Wolinsky and the Ariel Core Investigators (1999) The Ariel Project: A prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy. Journal of Infectious Diseases, 179 (2). pp. 319-328. ISSN 0022-1899

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Official URL: http://www.journals.uchicago.edu/JID/journal/issues/v179n2/980128/980128.html

Abstract

In a prospective cohort study, clinical and biologic factors that contribute to maternal-child transmission of human immunodeficiency virus type 1 (HIV-1) were studied. HIV-infected pregnant women and their infants were evaluated prospectively according to a standardized protocol. Of 204 evaluable women, 81% received zidovudine during their pregnancy. The infection rate among the 209 evaluable infants was 9.1%. By univariate analysis, histologic chorioamnionitis, prolonged rupture of membranes, and a history of genital warts were significantly associated with transmission. Additional factors associated with transmission that approached significance included a higher maternal virus load at delivery and the presence of cocaine in the urine. In a logistic regression model, histologic chorioamnionitis was the only independent predictor of transmission. Despite a significantly higher transmission rate at one site, no unique viral genotype was found at any site. Thus, chorioamnionitis was found to be the major risk factor for transmission among women receiving zidovudine.

Item Type:Article
Additional Information:

© 1999 by Infectious Diseases Society of America.

The Ariel Core Investigators are: Arthur Ammann, Irvin Chen, April Gifford, David Ho, Richard A. Koup, Paul Krogstad, Mark Muldoon, James Mullins, and Bruce Walker.

Subjects:MSC 2000 > 92 Biology and other natural sciences
MIMS number:2006.63
Deposited By:Dr Mark Muldoon
Deposited On:13 April 2006

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