Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

Derdeyn, Cynthia A. and Decker, Julie M. and Bibollet-Ruche, Frederic and Mokili, John L. and Muldoon, Mark and Denham, Scott A. and Heil, Marintha L. and Kasolo, Francis and Musonda, Rosemary and Hahn, Beatrice H. and Shaw, George M. and Korber, Bette T. and Allen, Susan and Hunter, Eric (2004) Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission. Science, 303. pp. 2019-2022. ISSN 0036-8075

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Abstract

Heterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

Item Type: Article
Additional Information: Supporting online material available at http://www.sciencemag.org/cgi/content/full/303/5666/2019/DC1
Uncontrolled Keywords: HIV/AIDS, transmission, vaccine design
Subjects: MSC 2010, the AMS's Mathematics Subject Classification > 92 Biology and other natural sciences
Depositing User: Dr Mark Muldoon
Date Deposited: 17 Apr 2006
Last Modified: 20 Oct 2017 14:12
URI: http://eprints.maths.manchester.ac.uk/id/eprint/223

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