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2006.66: Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

2006.66: Cynthia A. Derdeyn, Julie M. Decker, Frederic Bibollet-Ruche, John L. Mokili, Mark Muldoon, Scott A. Denham, Marintha L. Heil, Francis Kasolo, Rosemary Musonda, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, Susan Allen and Eric Hunter (2004) Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission. Science, 303. pp. 2019-2022. ISSN 0036-8075

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DOI: 10.1126/science.1093137

Abstract

Heterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

Item Type:Article
Additional Information:

Supporting online material available at http://www.sciencemag.org/cgi/content/full/303/5666/2019/DC1

Uncontrolled Keywords:HIV/AIDS, transmission, vaccine design
Subjects:MSC 2000 > 92 Biology and other natural sciences
MIMS number:2006.66
Deposited By:Dr Mark Muldoon
Deposited On:17 April 2006

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