2006.67: Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant
2006.67: Yunzhen Cao, Paul Krogstad, Bette T. Korber, Richard A. Koup, Mark Muldoon, Catherine Macken, Jia-Li Song, Zhanqun Jin, Jla-Qi Zhao, Sheila Clapp, Irvin S. Y. Chen, David D. Ho, Arthur J. Ammann and the Ariel Project Investigators (1997) Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant. Nature Medicine, 3 (5). pp. 549-552. ISSN 1078-8956
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Most HIV-1 infections of children result from mother-to-infant transmission, which may occur perinatally or postnatally, as a consequence of breast feeding1−8. In this study, the influence of maternal viral load on transmission of infection to infants from non-breast-feeding mothers was examined using samples of plasma and peripheral blood mononuclear cells (PBMCs) collected at several time points during pregnancy and the 6-month period after delivery. These samples were analyzed by several quantitative methods, including virus cultures of PBMCs and polymerase chain reaction (PCR) assays for HIV-1 RNA in plasma and DMA in PBMCs. The risk of transmission increased slightly with a higher viral load, but transmission and nontransmission occurred over the entire range of values for each assay. No threshold value of virus load was identified which discriminated between transmitters and nontransmitters. We also noted a significant rise in viral load and a decline in CD4+ lymphocytes in the six months after delivery. These findings suggest that a high maternal viral load is insufficient to fully explain vertical transmission of HIV-1. Additional studies are needed to examine the post-partum increase in viremia.
The Ariel Project is a Pediatric AIDS Foundation Sponsored project. Core Investigators include James Mullins, Bruce Walker, and Steve Wolinsky. Cohort Investigators are Arlene Bardeguez, Marilyn Crane, Celine Hanson, Hunter Hamill, Katherine Luzuriaga, Paul Palumbo, Russell Van Dyke, Susan Widameyer and Andrew Wiznia.
|Uncontrolled Keywords:||HIV-1, maternal transmission|
|Subjects:||MSC 2000 > 92 Biology and other natural sciences|
|Deposited By:||Dr Mark Muldoon|
|Deposited On:||17 April 2006|