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2006.236: Modelling the adaptive permeability of porcine iliac arteries to acute changes in mural shear

2006.236: Andrew L. Hazel, G.M. Grzybowski and M.H. Friedman (2003) Modelling the adaptive permeability of porcine iliac arteries to acute changes in mural shear. Annals of Biomedical Engineering, 31 (4). pp. 412-419. ISSN 0090-6964

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DOI: 10.1114/1.1560633

Abstract

The hypothesis that much of the uptake of macromolecules by the vascular wall takes place while the endothelial lining is adapting to changes in its hemodynamic environment is being tested by a series of in vivo measurements of the uptake of Evans-blue-dye-labeled albumin by porcine iliac arteries subjected to acute changes in blood flow. The uptake data are interpreted through an ad hoc model of the dynamic permeability response that is proposed to accompany alterations in mural shear.The model is able to correlate, with a single set of parameters, the vascular response to a variety of experimental protocols, including sustained step increases and decreases in shear, and alternations in shear of various periods. The best-fit parameters of the model suggest that the adaptive response to an increase in shear proceeds with a latency of sim 1.5 min and a time constant of sim 90 min that is substantially shorter than the response to a decrease in shear. © 2003 Biomedical Engineering Society. PAC2003: 8710+e, 8719Rr, 8719Uv

Item Type:Article
Uncontrolled Keywords:Atherogenesis - Hemodynamics - Endothelium - Wall shear stress
Subjects:MSC 2000 > 76 Fluid mechanics
MSC 2000 > 92 Biology and other natural sciences
MIMS number:2006.236
Deposited By:Miss Louise Stait
Deposited On:04 August 2006

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