Migration and proliferation dichotomy in tumor cell invasion

Fedotov, Sergei and Lomin, Alexander (2007) Migration and proliferation dichotomy in tumor cell invasion. Physical Review Letters, 98 (11). 118101/1-118101/4. ISSN 1079-7114

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We propose a two-component reaction-transport model for the migration-proliferation dichotomy in the spreading of tumor cells. By using a continuous time random walk (CTRW), we formulate a system of the balance equations for the cancer cells of two phenotypes with random switching between cell proliferation and migration. The transport process is formulated in terms of the CTRW with an arbitrary waiting-time distribution law. Proliferation is modeled by a standard logistic growth. We apply hyperbolic scaling and Hamilton-Jacobi formalism to determine the overall rate of tumor cell invasion. In particular, we take into account both normal diffusion and anomalous transport (subdiffusion) in order to show that the standard diffusion approximation for migration leads to overestimation of the overall cancer spreading rate.

Item Type: Article
Subjects: PACS 2010, the AIP's Physics and Astronomy Classification Scheme > 80 INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY > 87 Biological and medical physics
Depositing User: Ms Lucy van Russelt
Date Deposited: 16 Nov 2007
Last Modified: 20 Oct 2017 14:12
URI: http://eprints.maths.manchester.ac.uk/id/eprint/885

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