Longitudinal and Cross-Sectional Analysis of Cytotoxic T Lymphocyte (CTL) Responses and their Relationship to Vertical HIV Transmission

Jin, Xia and Roberts, Caroline G. P. and Nixon, Douglas F. and Cao, Yunzhen and Ho, David D. and Walker, Bruce D. and Muldoon, Mark and Korber, Bette T. M. and Koup, Richard A. and ARIEL Project Investigators, the (1998) Longitudinal and Cross-Sectional Analysis of Cytotoxic T Lymphocyte (CTL) Responses and their Relationship to Vertical HIV Transmission. Journal of Infectious Diseases, 178 (5). pp. 1317-1326. ISSN 0022-1899

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Abstract

The ARIEL Project for the Prevention of HIV Transmission from Mother to Infant was established to evaluate virologic and immunologic parameters during vertical transmission. To determine the strength and breadth of the cytotoxic T lymphocyte (CTL) response and its correlation with human immunodeficiency virus (HIV) transmission, a cross-sectional study was done of 31 HIV-infected pregnant women, of whom 15 transmitted and 16 did not transmit HIV to their infants. The precursor frequencies of CTL specific for HIV-1 gag, pol, nef, and env from 5 different isolates of the clade B of HIV-1 were determined by limiting dilution analysis. Results showed that variable levels of HIV-specific CTL response were present in HIV-infected pregnant women during and after pregnancy. In addition, CTL precursor frequencies specific for pol and nef were higher during pregnancy in nontransmitters than in transmitters. Thus, CTL responding to different HIV antigens may not be contributing equally to the prevention of vertical transmission.

Item Type: Article
Additional Information: © 1999 by Infectious Diseases Society of America. The ARIEL Project is a Pediatric AIDS Foundation Sponsored Project. Core Investigators also include James Mullins, Irvin Chen, and Steve Wolinsky. Cohort Investigators are Arlene Bardeguez, Marilyn Crane, Celine Hanson, Hunter Hamill, Katherine Luzuriaga, Paul Palumbo, Russell Van Dyke, Susan Widmayer, and Andrew Wiznia.
Subjects: MSC 2010, the AMS's Mathematics Subject Classification > 62 Statistics
MSC 2010, the AMS's Mathematics Subject Classification > 92 Biology and other natural sciences
Depositing User: Dr Mark Muldoon
Date Deposited: 04 Dec 2005
Last Modified: 20 Oct 2017 14:12
URI: http://eprints.maths.manchester.ac.uk/id/eprint/99

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